NLM DIR Seminar Schedule
UPCOMING SEMINARS
RECENT SEMINARS
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June 30, 2026 Jaya Srivastava
Disrupted Regulation of Essential Genes Mediates Dementias and Age-Associated Disorders -
June 11, 2026 Angela Jiang
Identification and Evolutionary Analysis of Steroid-Metabolism Enzymes in Gut Microbes -
June 10, 2026 Luda Diatchenko
New Insights on Pain Biology from Human Transcriptomics: How Stimulation of Immune Response Shapes Pain Resolution -
June 9, 2026 Pascal Mutz
Characterization of covalently closed circular RNA replicators detected in (meta)transcriptomic data -
June 4, 2026 Madeleine Clore
Explaining why AlphaFold struggles to predict mutational effects
Scheduled Seminars on June 15, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Computational analysis of sequence and structures of proteins is an effective method to decipher the biochemistry and biology of proteins. I will be presenting examples of such analysis from my past and current research, focusing on two distinct strategies that bacteria employ to combat external stress. One is a study of the Ter-dependent stress response system where I will present evidence that the ter gene products and their functional partners constitute previously underappreciated, chemical stress response and anti-viral defense systems of bacteria. The other is a study of proteins in sporulating bacteria like Bacillus that form spores to tide over stress due to nutrient starvation. I will present results from the sequence, structural and experimental analysis of some of the proteins that are important for the spore coat and cortex assembly.