NLM DIR Seminar Schedule
UPCOMING SEMINARS
RECENT SEMINARS
-
June 30, 2026 Jaya Srivastava
Disrupted Regulation of Essential Genes Mediates Dementias and Age-Associated Disorders -
June 11, 2026 Angela Jiang
Identification and Evolutionary Analysis of Steroid-Metabolism Enzymes in Gut Microbes -
June 10, 2026 Luda Diatchenko
New Insights on Pain Biology from Human Transcriptomics: How Stimulation of Immune Response Shapes Pain Resolution -
June 9, 2026 Pascal Mutz
Characterization of covalently closed circular RNA replicators detected in (meta)transcriptomic data -
June 4, 2026 Madeleine Clore
Explaining why AlphaFold struggles to predict mutational effects
Scheduled Seminars on Dec. 8, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi and provide evidence for CRISPR targeting of viroid-like RNAs.