NLM DIR Seminar Schedule
UPCOMING SEMINARS
RECENT SEMINARS
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June 30, 2026 Jaya Srivastava
Disrupted Regulation of Essential Genes Mediates Dementias and Age-Associated Disorders -
June 11, 2026 Angela Jiang
Identification and Evolutionary Analysis of Steroid-Metabolism Enzymes in Gut Microbes -
June 10, 2026 Luda Diatchenko
New Insights on Pain Biology from Human Transcriptomics: How Stimulation of Immune Response Shapes Pain Resolution -
June 9, 2026 Pascal Mutz
Characterization of covalently closed circular RNA replicators detected in (meta)transcriptomic data -
June 4, 2026 Madeleine Clore
Explaining why AlphaFold struggles to predict mutational effects
Scheduled Seminars on April 6, 2023
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
In a pending pandemic, early knowledge of age-specific disease parameters, e.g., susceptibility, infectivity, and the clinical fraction of symptomatic cases, supports targeted public health responses like school closures or sequestration of the elderly. Using age-stratified COVID-19 case counts collected in six countries before April 23, 2020, we present a linear analysis of the exponential phase that attempts to estimate the age-specific disease parameters given above. Conclusions concerning the age-dependence of case susceptibility appeared more robust than corresponding conclusions about infectivity. The analysis produced some results consistent with conclusions confirmed much later in the COVID-19 pandemic.