NLM DIR Seminar Schedule
UPCOMING SEMINARS
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April 8, 2025 Jaya Srivastava
TBD -
April 15, 2025 Pascal Mutz
TBD -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics -
April 22, 2025 Stanley Liang
TBD -
April 29, 2025 MG Hirsch
TBD
RECENT SEMINARS
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April 1, 2025 Roman Kogay
Horizontal transfer of bacterial operons into eukaryote genomes -
March 25, 2025 Yifan Yang
Adversarial Manipulation and Data Memorization in Large Language Models for Medicine -
March 11, 2025 Sofya Garushyants
Tmn – bacterial anti-phage defense system -
March 4, 2025 Sanasar Babajanyan
Evolution of antivirus defense in prokaryotes depending on the environmental virus load -
Feb. 25, 2025 Zhizheng Wang
GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases
Scheduled Seminars on May 10, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Wastewater-based epidemiology relies on the high-throughput sequencing (HTS) of pathogens from wastewater, and it has been widely applied during the SARS-CoV-2 pandemic. This approach has some advantages over conventional clinical-based epidemiology since it is a low-cost, non-invasive, and anonymous sampling opportunity that captures viral diversity from multiple symptomatic or asymptomatic individuals. However, there are challenges to the data analysis since viral sequences obtained are derived from multiple genomes. In this research, we have developed a bioinformatic framework to address some of those challenges, process the HTS data and detect the most likely variant of concern present in each location based on their defining single nucleotide variants, insertions, and deletions. In addition, we developed an approach to look at viral diversity at the community level using principal component analysis.