NLM DIR Seminar Schedule
UPCOMING SEMINARS
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April 8, 2025 Jaya Srivastava
Leveraging a deep learning model to assess the impact of regulatory variants on traits and diseases -
April 15, 2025 Pascal Mutz
TBD -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics -
April 22, 2025 Stanley Liang
TBD -
April 29, 2025 MG Hirsch
TBD
RECENT SEMINARS
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April 1, 2025 Roman Kogay
Horizontal transfer of bacterial operons into eukaryote genomes -
March 25, 2025 Yifan Yang
Adversarial Manipulation and Data Memorization in Large Language Models for Medicine -
March 11, 2025 Sofya Garushyants
Tmn – bacterial anti-phage defense system -
March 4, 2025 Sanasar Babajanyan
Evolution of antivirus defense in prokaryotes depending on the environmental virus load -
Feb. 25, 2025 Zhizheng Wang
GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases
Scheduled Seminars on May 5, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Insertion sequences of IS200/IS605 and IS607 usually contain only the genes that are required for their transposition and its regulation. These elements encode tnpA transposase, which is essential for mobilization, and often carry an accessory tnpB gene. Previous studies showed that TnpB might be a predecessor of the CRISPR–Cas9/Cas12 nucleases, and recently shown to be a RNA-directed nuclease that is guided by an RNA. In our work we provide a pipeline for systematic identification and characterization for TnpB genes. We obtain information of TnpB mobility obtained from completely sequenced genomes. We use phylogeny based methods to identify novel conserved TnpB families using their mobility and propose their novel function. This study expands our understanding of TnpB diversity and its applicability in genome editing.