NLM DIR Seminar Schedule
UPCOMING SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on May 5, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Insertion sequences of IS200/IS605 and IS607 usually contain only the genes that are required for their transposition and its regulation. These elements encode tnpA transposase, which is essential for mobilization, and often carry an accessory tnpB gene. Previous studies showed that TnpB might be a predecessor of the CRISPR–Cas9/Cas12 nucleases, and recently shown to be a RNA-directed nuclease that is guided by an RNA. In our work we provide a pipeline for systematic identification and characterization for TnpB genes. We obtain information of TnpB mobility obtained from completely sequenced genomes. We use phylogeny based methods to identify novel conserved TnpB families using their mobility and propose their novel function. This study expands our understanding of TnpB diversity and its applicability in genome editing.