NLM DIR Seminar Schedule
UPCOMING SEMINARS
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July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on Oct. 19, 2021
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Transposons are a class of mobile genetic elements that are capable of horizontal transfer between cells. Some transposons carry extra "cargo" genes that are transferred along with the element, but the diversity of cargo genes mobilized via transposition has not been comprehensively assessed. In this seminar, I will present a computational approach designed to identify transposons integrated in bacterial genomes, focusing on the model transposon Tn7. By identifying and delineating Tn7-like transposons integrated in bacterial genomes, the full diversity of cargo genes carried by these elements could be assessed, which included defense systems, antibiotic resistance genes and even other mobile genetic elements. Dissection of transposon cargo provides insight into prokaryotic horizontal gene transfer by expanding the known phyletic range of Tn7-like transposons, assessing the preferred routes and phylogenetic barriers to transposition, and characterizing the diversity of the mobilized genes.