NLM DIR Seminar Schedule
UPCOMING SEMINARS
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April 8, 2025 Jaya Srivastava
Leveraging a deep learning model to assess the impact of regulatory variants on traits and diseases -
April 15, 2025 Pascal Mutz
TBD -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics -
April 22, 2025 Stanley Liang
TBD -
April 29, 2025 MG Hirsch
TBD
RECENT SEMINARS
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April 1, 2025 Roman Kogay
Horizontal transfer of bacterial operons into eukaryote genomes -
March 25, 2025 Yifan Yang
Adversarial Manipulation and Data Memorization in Large Language Models for Medicine -
March 11, 2025 Sofya Garushyants
Tmn – bacterial anti-phage defense system -
March 4, 2025 Sanasar Babajanyan
Evolution of antivirus defense in prokaryotes depending on the environmental virus load -
Feb. 25, 2025 Zhizheng Wang
GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases
Scheduled Seminars on June 15, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Computational analysis of sequence and structures of proteins is an effective method to decipher the biochemistry and biology of proteins. I will be presenting examples of such analysis from my past and current research, focusing on two distinct strategies that bacteria employ to combat external stress. One is a study of the Ter-dependent stress response system where I will present evidence that the ter gene products and their functional partners constitute previously underappreciated, chemical stress response and anti-viral defense systems of bacteria. The other is a study of proteins in sporulating bacteria like Bacillus that form spores to tide over stress due to nutrient starvation. I will present results from the sequence, structural and experimental analysis of some of the proteins that are important for the spore coat and cortex assembly.