NLM DIR Seminar Schedule
UPCOMING SEMINARS
-
July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
-
July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on June 15, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Computational analysis of sequence and structures of proteins is an effective method to decipher the biochemistry and biology of proteins. I will be presenting examples of such analysis from my past and current research, focusing on two distinct strategies that bacteria employ to combat external stress. One is a study of the Ter-dependent stress response system where I will present evidence that the ter gene products and their functional partners constitute previously underappreciated, chemical stress response and anti-viral defense systems of bacteria. The other is a study of proteins in sporulating bacteria like Bacillus that form spores to tide over stress due to nutrient starvation. I will present results from the sequence, structural and experimental analysis of some of the proteins that are important for the spore coat and cortex assembly.