NLM DIR Seminar Schedule
UPCOMING SEMINARS
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May 2, 2025 Pascal Mutz
Characterization of covalently closed cirular RNAs detected in (meta)transcriptomic data -
May 2, 2025 Dr. Lang Wu
Integration of multi-omics data in epidemiologic research -
May 6, 2025 Leslie Ronish
TBD -
May 8, 2025 MG Hirsch
TBD -
May 13, 2025 Harutyun Saakyan
TBD
RECENT SEMINARS
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April 22, 2025 Stanley Liang, PhD
Large Vision Model for medical knowledge adaptation -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics -
April 8, 2025 Jaya Srivastava
Leveraging a deep learning model to assess the impact of regulatory variants on traits and diseases -
April 1, 2025 Roman Kogay
Horizontal transfer of bacterial operons into eukaryote genomes -
March 25, 2025 Yifan Yang
Adversarial Manipulation and Data Memorization in Large Language Models for Medicine
Scheduled Seminars on Dec. 8, 2022
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi and provide evidence for CRISPR targeting of viroid-like RNAs.