NLM DIR Seminar Schedule
UPCOMING SEMINARS
RECENT SEMINARS
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June 30, 2026 Jaya Srivastava
Disrupted Regulation of Essential Genes Mediates Dementias and Age-Associated Disorders -
June 11, 2026 Angela Jiang
Identification and Evolutionary Analysis of Steroid-Metabolism Enzymes in Gut Microbes -
June 10, 2026 Luda Diatchenko
New Insights on Pain Biology from Human Transcriptomics: How Stimulation of Immune Response Shapes Pain Resolution -
June 9, 2026 Pascal Mutz
Characterization of covalently closed circular RNA replicators detected in (meta)transcriptomic data -
June 4, 2026 Madeleine Clore
Explaining why AlphaFold struggles to predict mutational effects
Scheduled Seminars on March 19, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Cancer progression is an evolutionary process driven by the selection of cells adapted to gain growth advantage. We present the first formal study on the adaptation of gene expression in subclonal evolution. We model evolutionary changes in gene expression as stochastic Ornstein–Uhlenbeck processes, jointly leveraging the evolutionary history of subclones and single-cell expression data. Applying our model to sublines derived from single cells of a mouse melanoma revealed that sublines with distinct phenotypes are underlined by different patterns of gene expression adaptation, indicating non-genetic mechanisms of cancer evolution.
Interestingly, sublines previously observed to be resistant to anti-CTLA-4 treatment showed adaptive expression of genes related to invasion and non-canonical Wnt signaling, whereas sublines that responded to treatment showed adaptive expression of genes related to proliferation and canonical Wnt signalling. Our results suggest that clonal phenotypes emerge as the result of specific adaptivity patterns of gene expression.