NLM DIR Seminar Schedule
UPCOMING SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on Nov. 5, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Twenty-five years ago, the discovery that key animal and plant apoptosis protein domains had homologs in other branches of the Tree of Life (ToL), including bacteria, profoundly reshaped our understanding of the evolution of programmed cell death. However, the functional contexts of these domains in prokaryotes were poorly understood.
Over the past four years, our group has uncovered several novel prokaryotic systems which lay out an operational "grammar" and shared "vocabulary" of protein domains repeatedly shared in organisms with a multicellular lifestyle across the ToL. These insights throw new light on the interconnected evolution of multicellularity, altruism, and immunity, with special emphasis on the role of these systems in the earliest emergence of apoptosis/immunity systems in animals.