NLM DIR Seminar Schedule
UPCOMING SEMINARS
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Dec. 10, 2024 Amr Elsawy
AI for Age-Related Macular Degeneration on Optical Coherence Tomography -
Dec. 17, 2024 Joey Thole
TBD -
Jan. 7, 2025 Qiao Jin
TBD -
Jan. 14, 2025 Ryan Bell
TBD -
Jan. 21, 2025 Qingqing Zhu
TBD
RECENT SEMINARS
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Dec. 3, 2024 Sarvesh Soni
Toward Relieving Clinician Burden by Automatically Generating Progress Notes -
Nov. 19, 2024 Benjamin Lee
Reiterative Translation in Stop-Free Circular RNAs -
Nov. 12, 2024 Devlina Chakravarty
Fold-switching reveals blind spots in AlphaFold predictions -
Nov. 5, 2024 Max Burroughs
Revisiting the co-evolution of multicellularity and immunity across the tree of life -
Nov. 4, 2024 Finn Werner
African Swine Fever Virus transcription – from transcriptome to molecular structure
Scheduled Seminars on Nov. 5, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Twenty-five years ago, the discovery that key animal and plant apoptosis protein domains had homologs in other branches of the Tree of Life (ToL), including bacteria, profoundly reshaped our understanding of the evolution of programmed cell death. However, the functional contexts of these domains in prokaryotes were poorly understood.
Over the past four years, our group has uncovered several novel prokaryotic systems which lay out an operational "grammar" and shared "vocabulary" of protein domains repeatedly shared in organisms with a multicellular lifestyle across the ToL. These insights throw new light on the interconnected evolution of multicellularity, altruism, and immunity, with special emphasis on the role of these systems in the earliest emergence of apoptosis/immunity systems in animals.