NLM DIR Seminar Schedule
UPCOMING SEMINARS
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Dec. 10, 2024 Amr Elsawy
AI for Age-Related Macular Degeneration on Optical Coherence Tomography -
Dec. 17, 2024 Joey Thole
TBD -
Jan. 7, 2025 Qiao Jin
TBD -
Jan. 14, 2025 Ryan Bell
TBD -
Jan. 21, 2025 Qingqing Zhu
TBD
RECENT SEMINARS
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Dec. 3, 2024 Sarvesh Soni
Toward Relieving Clinician Burden by Automatically Generating Progress Notes -
Nov. 19, 2024 Benjamin Lee
Reiterative Translation in Stop-Free Circular RNAs -
Nov. 12, 2024 Devlina Chakravarty
Fold-switching reveals blind spots in AlphaFold predictions -
Nov. 5, 2024 Max Burroughs
Revisiting the co-evolution of multicellularity and immunity across the tree of life -
Nov. 4, 2024 Finn Werner
African Swine Fever Virus transcription – from transcriptome to molecular structure
Scheduled Seminars on Nov. 19, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
This study explores covalently closed circular RNAs (cccRNAs) that lack out-of-frame stop codons, a feature that may enable reiterative translation. While reiterative translation has been demonstrated for one satellite RNA, our analysis reveals that overlapping circular ORFs lacking hidden stop codons are more frequent than expected by chance, especially as ORF length increases. Using viroid-like circular RNA datasets, we identify mitovirus RNA-dependent RNA polymerase (RdRP) sequences that preserve this stop-free property. Statistical analysis indicates that amino acid and codon usage biases contribute to maintaining this feature. These findings suggest that reiterative translation, alongside reiterative transcription, may be a strategy employed by mitovirus-like cccRNAs.