NLM DIR Seminar Schedule
UPCOMING SEMINARS
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Feb. 18, 2025 Samuel Lee
Efficient predictions of alternative protein conformations by AlphaFold2-based sequence association -
Feb. 25, 2025 Zhizheng Wang
GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases -
March 4, 2025 Sofya Garushyants
TBD -
March 11, 2025 Sanasar Babajanyan
TBD -
March 18, 2025 MG Hirsch
TBD
RECENT SEMINARS
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Feb. 11, 2025 Po-Ting Lai
Enhancing Biomedical Relation Extraction with Directionality -
Feb. 4, 2025 Victor Tobiasson
On the dominance of Asgard contributions to Eukaryogenesis -
Jan. 28, 2025 Kaleb Abram
Leveraging metagenomics to investigate the co-occurrence of virome and defensome elements at large scale -
Jan. 21, 2025 Qiao Jin
Artificial Intelligence for Evidence-based Medicine -
Jan. 17, 2025 Xuegong Zhang
Using Large Cellular Models to Understand Cell Transcriptomics Language
Scheduled Seminars on Jan. 28, 2025
In-person: Building 38A/B2N14 NCBI Library or Zoom
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
While bacteria have evolved a wide array of defense mechanisms in response to viral infections, viruses have developed counter-defense mechanisms to counter act these bacterial defense mechanisms. This never-ending dynamic occurs at a rapid pace and has led to a wide diversity of both bacteria and viruses. Genomic sequencing has enabled researchers to investigate a wide range of biological questions which could not be previously studied. As this technology improved in both performance and price, the overall amount of data available to researchers has skyrocketed. The emergence of metagenomic sequencing has revealed previously unknown biological diversity as well as provided a methodology to easily recover both virial and bacterial genomes. The combination of both the large amounts of data available and the ability to obtain both the genomic sequences off both bacteria and viruses within a given environment, enables the characterization of both the bacterial defense systems (defensome) and the viruses (virome) present within a given environment at an unprecedented scale. The investigation into virome and defensome elements which co-occur across a wide range of environments provides an increased understanding of the dynamics between bacteria and viruses.