NLM DIR Seminar Schedule
UPCOMING SEMINARS
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July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on Feb. 11, 2025
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Biological relation networks contain rich information for understanding the biological mechanisms behind the relationship of entities such as genes, proteins, diseases, and chemicals. The vast growth of biomedical literature poses significant challenges updating the network knowledge. The recent Biomedical Relation Extraction Dataset (BioRED) provides valuable manual annotations, facilitating the development of machine-learning and pre-trained language model ap-proaches for automatically identifying novel document-level (inter-sentence context) relationships. Nonetheless, its annotations lack directionality (subject/object) for the entity roles, essential for study-ing complex biological networks. Herein we annotate the entity roles of the relationships in the Bi-oRED corpus and subsequently propose a novel multi-task language model with soft-prompt learning to jointly identify the relationship, novel findings, and entity roles. Our results include an enriched Bi-oRED corpus with 10,864 directionality annotations. Moreover, our proposed method outperforms existing large language models such as the state-of-the-art GPT-4 and Llama-3 on two benchmarking tasks.
Microsoft Teams
Meeting ID: 224 443 106 522
Passcode: 5he64w7k
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