NLM DIR Seminar Schedule
UPCOMING SEMINARS
RECENT SEMINARS
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May 2, 2025 Pascal Mutz
Characterization of covalently closed cirular RNAs detected in (meta)transcriptomic data -
May 2, 2025 Dr. Lang Wu
Integration of multi-omics data in epidemiologic research -
April 22, 2025 Stanley Liang, PhD
Large Vision Model for medical knowledge adaptation -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics -
April 8, 2025 Jaya Srivastava
Leveraging a deep learning model to assess the impact of regulatory variants on traits and diseases
Scheduled Seminars on Oct. 16, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Upon covering current concepts of the virus origins and a logic of virus evolution, the focus of the talk will be on recent explosive growth in the known diversity of the global RNA virosphere. This growth resulted in a dramatic shift in the understanding of the evolutionary pathways of the RNA viruses and development of the virus classification (megataxonomy) based on their natural histories. More specific aspects of the presentation will include development of the comprehensive phylogeny for all RNA viruses (currently kingdom Orthornavirae) that is used as a scaffold for revealing how RNA virus genomes diversify, increase their complexity and expand their host ranges along with evolution of the biosphere. We will also consider the structure and functions of the known orthornavirus proteome. Finally, we will briefly discuss the greatly expanded realm of the subviral RNA replicons, the viroid-like circular RNAs.