NLM DIR Seminar Schedule
UPCOMING SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus
RECENT SEMINARS
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July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression -
May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences
Scheduled Seminars on Oct. 16, 2024
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Upon covering current concepts of the virus origins and a logic of virus evolution, the focus of the talk will be on recent explosive growth in the known diversity of the global RNA virosphere. This growth resulted in a dramatic shift in the understanding of the evolutionary pathways of the RNA viruses and development of the virus classification (megataxonomy) based on their natural histories. More specific aspects of the presentation will include development of the comprehensive phylogeny for all RNA viruses (currently kingdom Orthornavirae) that is used as a scaffold for revealing how RNA virus genomes diversify, increase their complexity and expand their host ranges along with evolution of the biosphere. We will also consider the structure and functions of the known orthornavirus proteome. Finally, we will briefly discuss the greatly expanded realm of the subviral RNA replicons, the viroid-like circular RNAs.