NLM DIR Seminar Schedule
UPCOMING SEMINARS
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Jan. 14, 2025 Ryan Bell
Comprehensive analysis of the YprA-like helicase family provides deep insight into the evolution and potential mechanisms of widespread and largely uncharacterized prokaryotic antiviral defense systems -
Jan. 16, 2025 Qingqing Zhu
GPTRadScore and CT-Bench: Advancing Multimodal AI Evaluation and Benchmarking in CT Imaging -
Jan. 17, 2025 Xuegong Zhang
Using Large Cellular Models to Understand Cell Transcriptomics Language -
Jan. 21, 2025 Qiao Jin
Artificial Intelligence for Evidence-based Medicine -
Jan. 28, 2025 Kaleb Abram
TBD
RECENT SEMINARS
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Jan. 14, 2025 Ryan Bell
Comprehensive analysis of the YprA-like helicase family provides deep insight into the evolution and potential mechanisms of widespread and largely uncharacterized prokaryotic antiviral defense systems -
Dec. 17, 2024 Joey Thole
Training set associations drive AlphaFold initial predictions of fold-switching proteins -
Dec. 10, 2024 Amr Elsawy
AI for Age-Related Macular Degeneration on Optical Coherence Tomography -
Dec. 3, 2024 Sarvesh Soni
Toward Relieving Clinician Burden by Automatically Generating Progress Notes -
Nov. 19, 2024 Benjamin Lee
Reiterative Translation in Stop-Free Circular RNAs
Scheduled Seminars on Nov. 28, 2023
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi.