NLM DIR Seminar Schedule
UPCOMING SEMINARS
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Sept. 9, 2025 Chih-Hsuan Wei
No Data Left Behind: FAIR-SMart Enables FAIR Access to Supplementary Materials for Research Transparency -
Sept. 16, 2025 James Leaman JR.
TBD -
Sept. 23, 2025 Martha Nelson
TBD -
Sept. 30, 2025 Erez Persi
TBD -
Oct. 7, 2025 Liana Yeganova
TBD
RECENT SEMINARS
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July 15, 2025 Noam Rotenberg
Cell phenotypes in the biomedical literature: a systematic analysis and the NLM CellLink text mining corpus -
July 3, 2025 Matthew Diller
Using Ontologies to Make Knowledge Computable -
July 1, 2025 Yoshitaka Inoue
Graph-Aware Interpretable Drug Response Prediction and LLM-Driven Multi-Agent Drug-Target Interaction Prediction -
June 10, 2025 Aleksandra Foerster
Interactions at pre-bonding distances and bond formation for open p-shell atoms: a step toward biomolecular interaction modeling using electrostatics -
June 3, 2025 MG Hirsch
Interactions among subclones and immunity controls melanoma progression
Scheduled Seminars on Nov. 28, 2023
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi.